Relationship Between 25Hydroxyvitamin D and Peripheral Arterial Disease As Measured by Anklebrachial Index

Meeting: Hospital Medicine 2012, April 1-4, San Diego, Calif.

Abstract number: 97624

Background:

Low serum 25(OH) D levels are associated with higher prevalence of peripheral arterial disease (PAD). It has been proposed that this inverse relationship is non–linear in that the association diminishes with rising 25(OH) D levels. To test this hypothesis, we examined the relationship between 25(OH) D and PAD as measured by Ankle–Brachial index (ABI) in healthy adult US population.

Methods:

We analyzed data from the continuous National Health and Nutrition Examination Survey for years 2001–2004. ABI was treated as a continuous variable and the minimum of the two reported ABI values was chosen for each individual. To examine the non–linear relationship between 25(OH) D and ABI, we introduced a spline, with a single knot at the median serum levels (21 ng/mL) of 25(OH) D. The effect of 25(OH) D was calculated for every 10 ng/mL increase below and above spline. Regression models were adjusted for age, sex, race, body mass index, blood pressure, serum glucose, c–reactive protein, smoking, total cholesterol, and renal function.

Results:

Of the 4979 individuals, 48% were females and 58% were Caucasians. The mean (SD) age, 25(OH) D, c–reactive protein, and ABI was 60.4(13.22) years, 22.1(8.68) ng/mL, 0.46(0.81) mg/dL and 1.07(0.15), respectively. In both unadjusted and adjusted linear regression models without a spline, we found that 25(OH) D was associated with a significant increase in ABI (0.018, 95% CI: 0.013 to 0.023 and 0.018, 95% CI: 0.012 to 0.024, respectively) for each 10 ng/mL increase in serum 25(OH) D. In the unadjusted linear regression model with spline, any change in ABI with rising serum 25(OH) D was much larger before 21 ng/mL (0.04, 95% CI: 0.03 to 0.05) than after 21 ng/mL (0.01, 95% CI: 0.003 to 0.013), for each 10 ng/mL increase in serum 25(OH) D. In adjusted analysis, the association between ABI and 25(OH) D remained statistically significant before 21 ng/mL (0.04, 95% CI: 0.02 to 0.05 ) but not after 21 ng/mL (0.008, 95% CI: – 0.0008 to 0.017) for each 10 ng/mL increase in 25(OH) D.

Conclusions:

ABI increases as serum 25(OH) D levels increases, however, the change is nonlinear and it appears to plateau after 21 ng/mL of 25(OH) D in healthy adults. It is likely that the benefit of 25(OH) D supplementation for the prevention of PAD may only be seen in individuals with 25(OH) D levels below 21 ng/mL.

To cite this abstract:

Amer M, Qayyum R. Relationship Between 25Hydroxyvitamin D and Peripheral Arterial Disease As Measured by Anklebrachial Index. Abstract published at Hospital Medicine 2012, April 1-4, San Diego, Calif. Abstract 97624. Journal of Hospital Medicine. 2012; 7 (suppl 2). https://www.shmabstracts.com/abstract/relationship-between-25hydroxyvitamin-d-and-peripheral-arterial-disease-as-measured-by-anklebrachial-index/. Accessed November 20, 2019.

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