Diastolic Dysfunction As a Poor Prognostic Factor in Patients with Acute Pulmonary Embolism

1Cleveland Clinic, Cleveland, OH
2University of Illinois, Champaign, IL

Meeting: Hospital Medicine 2014, March 24-27, Las Vegas, Nev.

Abstract number: 51

Background:

Congestive heart failure has been used to identify high‐risk patients in acute pulmonary embolism. Diastolic dysfunction is one of the major causes of congestive heart failure but has been poorly understood. The implications of diastolic dysfunction in acute pulmonary embolism have not been investigated before.

Methods:

Patients who were admitted with the diagnosis of acute pulmonary embolism between January 2009 and July 2011 were included in our retrospective study. A total of 205 patients were reported diagnosed with acute pulmonary embolism during above period. We reviewed medical records to investigate whether diastolic dysfunction as assessed by echocardiogram increases in‐hospital mortality.

Results:

A total of 205 patients were diagnosed with acute pulmonary embolism between January 2009 and July 2011. Out of 205 patients, 107 patients (52.2 %) underwent transthoracic echocardiogram within 72 hours of diagnosis. These 107 patients were our target patient population to compare in‐hospital mortality between patients without diastolic dysfunction and with diastolic dysfunction as assessed by echocardiogram. Out of 107 patients, 10 patients died during hospitalization with in‐hospital mortality rate of 9.3 %. Among 84 patients without diastolic dysfunction as assessed by echocardiogram, six patients died with in‐hospital mortality rate of 7.1 %. Meanwhile, among 23 patients with diastolic dysfunction as assessed by echocardiogram, four patients died with in‐hospital mortality rate of 17.4 %. The odds ratio was calculated as 2.74 with 95% confidence interval of 0.70 – 10.67.

Conclusions:

For patients with acute pulmonary embolism, diastolic dysfunction as assessed by echocardiogram could indicate a poor prognosis increasing in‐hospital mortality by 2.74 times. Further study is needed to determine whether thrombolytic therapy can decrease in‐hospital mortality in patients with diastolic dysfunction.

To cite this abstract:

Cho J, Kocheril A. Diastolic Dysfunction As a Poor Prognostic Factor in Patients with Acute Pulmonary Embolism. Abstract published at Hospital Medicine 2014, March 24-27, Las Vegas, Nev. Abstract 51. Journal of Hospital Medicine. 2014; 9 (suppl 2). https://www.shmabstracts.com/abstract/diastolic-dysfunction-as-a-poor-prognostic-factor-in-patients-with-acute-pulmonary-embolism/. Accessed May 26, 2019.

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