Case Presentation: A 80 year-old male with history of stage IIIBE mantle cell lymphoma (MCL) diagnosed after presenting with left upper quadrant abdominal pain associated with weight loss, night sweats, fevers, and fatigue. He completed six cycles of
Discussion: Mantle cell lymphoma (MCL) is a rare, incurable, and rapidly progressing disease arising from mature B-lymphocytes that comprises 3–10% of all non-Hodgkin’s lymphoma subtypes. At the time of diagnosis, the disease is usually in the advanced stage in up to 70% of the patients and frequently associated with generalized lymphadenopathy, splenomegaly and involvement of the bone marrow, peripheral blood, Waldeyer’s ring or gastrointestinal tract. Rarely, involvement of the skin, breast, and central nervous system has been described. Patients who develop skin lesions with widespread MCL typically have a poor prognosis. Recommended treatments include induction chemotherapy followed by consolidation with autologous bone marrow transplant or alternative regimens such as bendamustine-
Conclusions: This case serves to show that MCL is an uncommon, difficult
– to –treat, non-Hodgkin lymphoma with a heterogeneous presentation ranging from asymptomatic disease to myriad clinical manifestations resulting from extranodal disease. Since cutaneous lesions are rare and can represent the first manifestation of new or recurrent MCL, awareness of this rare presentation is crucial for early diagnosis and treatment.
To cite this abstract:Olazagasti C, Velazquez AI, Bernabe C, Zahr AA, Shapira I. Cellulitis? Think Again! an Unusual Presentation of Recurrent Mantle Cell Lymphoma. Abstract published at Hospital Medicine 2016, March 6-9, San Diego, Calif. Abstract 716. https://www.shmabstracts.com/abstract/cellulitis-think-again-an-unusual-presentation-of-recurrent-mantle-cell-lymphoma/. Accessed February 18, 2019.